The long period observation of autologous peripheral blood stem cell transplantation by intracoronary infusion in pa-tients with acute myocardial infarction
CUI Lijie
LI Zhanquan
ZHU Fang
DUAN Na
Abstract：Objective To observe the effect of percutaneous intracoronary transplantation of autologous peripheral blood stem cell ( PBSC) on treatment of acute myocardial infarction ( AMI) .Methods Seventy cases of AMI were divided in-to transplantation group and control group with 35 cases in each group , stem cell transplantation group underwent the conven-tional therapy for acute myocardial infarction ( drug and interventional therapy ) combined with granulocyte colony-stimulating factor (G-CSF) subcutaneous injection of mobilization of autologous bone marrow stem cells last for 5 days, suspense separa-ted peripheral blood stem cells at the sixth days , over the wire balloon catheter center cavity , stem cell suspension was injected into the infarct related artery ( IRA) , peripheral blood stem cell transplantation were performed;the control group treated with routine method ( anti-drug and interventional ) treatment.During 5.2 years before and after transplantation ( 4.8 -5.5 years), echocardiography was performed to evaluate left ventricular configuration and function of segmental ventricular wall motion score, survival rate and cardiac events between the 2 groups of patients.Results Follow-up was last for 5.2 years, stem cell transplantation group were 30 cases, 28 cases in the control group .The 2 groups had no death cases , the control group had 6 cases (21.4%) of acute left heart failure, higher than the transplantation group of 1 cases (3.3%, P <0.05). Stem cell transplantation group ’s left ventricular ejection fraction (LVEF) was increased from (50.0 ±8.2)% to (56.0 ± 8.9)%( P <0.05), left ventricular wall motion score index (WMSI) was decreased from (1.219 ±0.190) to (1.111 ± 0.108) ( P <0.05).End systolic volume (LVESV) was decreased from (63.8 ±24.9) ml to (53.1 ±24.6) ml ( P <0.05), End diastolic volume (LVEDV) had no significant change from (134.2 ±36.7) ml to (119.2 ±30.3) ml ( P >0.05).LVEF, WMSI, EDV and ESV showed no significant changes in the control group intervention before and after 5.2 years of follow-up.Conclusion It demonstrated that the percutaneous intracoronary transplantation of autologous peripheral blood stem cell for the treatment of AMI can relieve ventricular remodeling and improve heart function .
Keywords：Myocardial infarctionacutePeripheral blood stem cellHeart functionTransplantation
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 891-893 )