Study on the relationship between plasma homocysteine and coronary artery lesions

WANG Huiqing; WANG Yanna; JIN Yaolai; DENG Chenghui

doi:10.3969/j.issn.1671-6450.2014.09.003

Abstract：Objective To investigate the correlation between plasma homocysteine in patients with coronary artery disease ( Hcy) associated with the severity of coronary artery lesion .Methods 178 patients with coronary angiography con-firmed coronary heart disease were enrolled as CHD group , and according to the number of diseased arteries , they were divid-ed into 1 vessel disease subgroup (48 cases), 2-vessel disease subgroup (57 cases), 3-vessel disease subgroup (73 cases). The same period 48 cases of normal patients were selected non-CHD group.Levels of plasma Hcy, total cholesterol (TC), three triacylglycerol (TG), high density lipoprotein (HDL) were detected and compared between the 2 groups, and to deter-mine the extent of coronary artery stenosis , record the Gensini coronary artery score .Results The levels of plasma Hcy , TC, TG of coronary heart disease group were higher than that in non CHD group , HDL was lower than that in non CHD group , the differences were statistically significant ( P <0.05).Coronary heart disease patients along with the severity of coronary artery disease , plasma Hcy level and Gensini score were increased , 1 vessel disease subgroup <2 vessel disease subgroup <3 ves-sel disease subgroup, and differences between former and non CHD group were statistically significant ( P <0.05).Logistic regression analysis revealed that Hcy , TC, TG were risk factors of coronary artery lesions ,while HDL was protective factor of coronary artery lesions;the differences were statistically significant ( P <0.05).Conclusion High Hcy is an independent risk factor of coronary heart disease , and increased with the severity of coronary artery lesions , according to detect Hcy level , the severity of coronary artery disease can be assessed .