Therapeutic effect of pregabalin and alpha lipoic acid on diabetes mellitus with painful neuropathy
YE Mao
ZHANG Min
YU Jing
Abstract：Objective To observe the efficacy and safety of pregabalin combined lipoic acid in the treatment of pain -ful diabetic neuropathy .Methods Eighty-eight cases of painful diabetic neuropathy were randomly divided into the pregabalin group with 28 cases (group A), lipoic acid group of 30 patients (group B) and pregabalin combined lipoic acid group of 30 patients ( group C) .Three groups of patients received the same basic treatment , group A received oral pregabalin , group B was treated with lipoic acid infusion , 2 weeks later changed to oral , group C was treated with pregabalin and lipoic acid treat-ment.The pain visual analog scale (VAS), changes of nerve conduction velocity and adverse reaction were observed before and after treatment and 2 week, 4 weeks after treatment .Results Compared with before treatment , after treated for 2 weeks and 4 weeks, 3 groups of patients'VAS were significantly decreased ( P <0.05), and group C<group A <group B ( P <0.05), and 4 weeks after treatment, the total efficiency were in the order of group C (86.7%)>group A (71.4%) >group B (46.7%) ( P <0.05).Compared with before treatment , nerve conduction velocity was increased in group B and C , the nerve conduction velocity in group B and C better than in group A , the differences were statistically significant ( P <0.05). The total adverse reaction rate had no significant difference among the 3 groups ( P >0.05).Conclusion Pregabalin com-bined lipoic acid revealed good effect in the treatment of diabetic neuropathic pain .
Keywords：PregabalinAlpha lipoic acidPainful diabetic peripheral neuropathy
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 820-823 )