Therapeutic effect of recombinant human erythropoietin combined with iron preparations on maintenance hemodialy-sis patients

LI Caihong; FENG Xiangfeng; XUE Song

doi:10.3969/j.issn.1671-6450.2014.08.014

Abstract：Objective To study the effect of recombinant human erythropoietin and iron preparations on maintenance hemodialysis patients .Methods One hundred and twenty hemodialysis patients were included in the study; They were ran-domly divided into 2 groups , 60 cases in each group:recombinant human erythropoietin and iron preparations for the observa-tion group, recombinant human erythropoietin treatment for the control group , treatment lasted for 10 weeks.After that, blood indexes, therapeutic effect, quality of life were compared between the 2 groups of patients.Results (1) Clinical effect:the total effective rate of observation group was 76.7%, significantly higher than that in control group 60.0%( P <0.05);(2) The blood index:compared with before treatment , the observation group of hemoglobin ( Hb) , hematocrit ( HCT) , serum iron (SI), serum ferritin (SF), transferrin saturation (TSAT), total iron binding capacity (TIBC), C reactive protein (CRP) were significantly improved ( P <0.05, P <0.01), and higher than that of control group ( P <0.05, P <0.01); Hb, HCT, TIBC in the control group improved significantly ( P <0.05), the other indexes were not improved statistically signifi-cant ( P >0.05);(3) Quality of life: compared with before treatment , the patients in observation group's self-realization, health responsibility, exercise, nutrition, interpersonal relationship, managing stress scores were increased significantly , and higher than that of control group ( P <0.05);in the control group, sports and nutrition had no significant difference ( P >0.05), others had statistical significance ( P <0.05, P <0.01).Conclusion Recombinant human erythropoietin and iron preparations for the treatment of patients with maintenance hemodialysis can helps to promote blood , improve anemia , improve the quality of life , but the assessment of iron metabolism indices should be to strengthen in the course of treatment .