Serum growth differentiation factor-15 and creatine kinase MB, cardiac troponin I, myoglobin levels in patients with acute myocardial infarction
WU Demei
ZHOU Qi
CHEN Chao
Abstract：Objective To investigate the relationship between acute myocardial infarction ( AMI ) patients serum growth differentiation factor-15 (GDF-15), the myocardial infarction three [isoenzyme of creatine kinase (CK-MB), troponin I (cTnI), myoglobin (Mb)] expression.Methods 116 cases of AMI patients as AMI group, they were divided into 2 sub-groups, the ST segment elevation myocardial infarction (STEMI group) with 58 cases, non ST segment elevation myocardial infarction (NSTEMI) group with 58 cases, using enzyme-linked immunosorbent assay (ELISA method) to determine the ser-um GDF-15 level, CK-MB, cTnI, Mb levels were determined using fluorescence immunoassay method;and 106 healthy sub-jects as healthy controls were compared .Results AMI group's GDF-15, CK-MB, cTnI, Mb levels were increased than health-y control group significantly ( P <0.01), where STEMI sub group were increased obviously than in NSTEMI group ( P <0.05).Correlation analysis showed that GDF-15 and CK-MB, cTnI, Mb were positively correlated ( r =0.558, r =0.579, r =0.545, P <0.01).Conclusion In the pathogenesis of AMI, blood GDF-15, CK-MB, cTnI, Mb, and STEMI were in-creased obviously .GDF-15 and CK-MB, cTnI, Mb were positively correlated , the combined detection of these indexes is helpful for early diagnosis and risk stratification of AMI .
Keywords：Myocardial infarctionacuteGrowth differentiation factor-15Creatine kinase isoenzymeTroponin IMyoglobinCorrelation analysis
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 790-792 )