Administration of flurbiprofen axetil at different time in colorectal surgery:effect with postoperative cytokine release
ZHANG Ruiqin
LIN Xue
CHANG Pan
LI Di
LIU Mingyuan
PAN Hong
WANG Weina
Abstract：Objective To explore the different time to administrate the flurbiprofen axetil ( FA) injection effects on the expression of plasma inflammatory cytokines in colorectal tumor resection patients .Methods Selected elective colorectal cancer resection patients ( n =40 ) , they were randomly divided into 2 groups , 20 patients in each group .Group A: open skin before operation for 30 min FA 100 mg; group B: after operation skin for 30 min FA 100 mg.Postoperative sufentanil (SF) were performed in patient controlled intravenous analgesia (PCIA).Comparison of 6 h, 24 h of plasma interleukin 2 (IL-2), interleukin 6 (IL-6), interleukin 10 (IL-10), tumor necrosis factor (TNF-α), macrophage-colony stimulating factor ( M-CSF) concentration between the 2 groups before and after the operation .Results Compared with before treatment , the 2 groups'IL 2 levels after 6 h, 24 h were lower, while IL-6 and IL-10 levels were elevated ( P <0.01);compared with group B, after 6 h, 24 h, group A's IL-2 increased, IL-6 reduced ( P <0.05);and compared with group B, after operation for 6h, group A's IL-10 levels was increased ( P <0.05).Patients in the 2 groups at each time point, TNF-αand M-CSF levels showed no statistically significant differences ( P >0.05).Conclusion Intravenous injection of FA 100 mg before operation, and com-bined with patient-controlled intravenous SF analgesia can reduce the expression of inflammatory factor on colorectal tumor pa -tients, while improving the anti-inflammatory cytokines , and promote the recovery of immune function of postoperative patient .
Keywords：Flurbiprofen axetilTumor resectioncolorectalPreemptive analgesiaCytokine
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 710-713 )