The effects of Niaoduqing granules on micro-inflammatory state and vascular endothelial growth factor in aged pa-tients with diabetic nephropathy
ZHANG Chen
WANG Meiling
MA Hua
XIA Xinbao
MA Jing
Abstract：Objective To observe the effect of Niaoduqing granules on micro-inflammatory state and vascular endo-thelial growth factor ( VEGF) in aged patients with diabetic nephropathy ( DN) .Methods Elderly patients with clinical stage DN 102 cases were randomly divided into 2 groups, 50 cases in conventional treatment group , 52 cases in the treatment group received the routine treatment plus Niaoduqing granules, two groups of patients were treated for 12 weeks, another 30 cases of healthy elderly people were enrolled as healthy controls .Compared of serum micro inflammatory markers interleukin-1β( IL-1β), interleukin-6 (IL-6), C reactive protein (CRP), tumor necrosis factor alpha (TNF-α) levels among the 3 groups, and these proinflammatory cytokines and VEGF and urinary albumin excretion rate ( UAER) were analyzed .Observe the change of IL-1 β, IL-6, CRP, TNF-α,VEGF and UAER levels in the 2 groups of patients before and after treatment .Results (1) 2 groups of elderly patients with clinical stage DN IL-1 β, IL-6, CRP, TNF-α, VEGF, UAER levels were significantly higher than that of the control group , the difference was statistically significant ( P <0.05);there was no significant difference be-tween the 2 groups ( P >0.05).(2)For 12 weeks, the conventional treatment group's IL-1β, VEGF, UAER decreased sig-nificantly ( P <0.05), while IL-6, CRP, TNF-αhad no significant changes ( P >0.05);Niaoduqing granules treatment group's IL-1 β, IL-6, CRP, TNF-α, VEGF, UAER decreased significantly , the difference was statistically significant ( P <0.05).All of the indexes in the Niaoduqing granules treatment group decreased obviously than routine treatment group ( P <0.05).(3) The result of correlation analysis showed that , VEGF and IL-1β( r =0.41, P <0.01), IL-6 ( r =0.28, P <0.01), CRP ( r =0.33, P <0.01), TNF-α( r =0.36, P <0.01) was positively correlated with UAER and IL-1β( r =0.39, P <0.01), IL-6 ( r =0.32, P <0.01), CRP ( r =0.29, P <0.01), TNF-α( r =0.37, P <0.01) were posi-tively correlated;VEGF was positively correlated with UAER ( r =0.55, P <0.01).Conclusion The aged patients with DN have suffered different degree of micro-inflammatory state and increased VEGF , Niaoduqing granules could effectively im-prove the micro inflammatory state .
Keywords：Niaoduqing granulesDiabetic nephropathyInflammatory reactionVascular endothelial growth factor
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 697-699,703 )