Effect of thymalfasin on the immune function of patients with advanced non-small cell lung cancer
ZHAO Mingli
BI Qing
TIAN Qing
BAO Mingliang
Abstract：Objective To investigate the effect of thymalfasin on the immune function of patients with advanced non -small cell lung cancer (NSCLC ).Methods 100 NSCLC patients were randomly divided into 2 groups, 52 cases in the treat-ment group , 48 cases in the control group , the 2 groups were given combined chemotherapy , the treatment group also used of thymalfasin subcutaneous injection , T cell subsets joint was measured after 4 courses of treatment , and to observe the occur-rence of the infection.Results (1) Compared the change of immune function: the control group after treatment , CD4+and CD8+did not change significantly ( P >0.05),CD4+/CD8+ratio decreased ( P <0.05), in treatment group,CD 4+and CD 4+/CD8+increased ( P <0.05), CD8+did not change significantly ( P >0.05), in the treatment group, CD4+and CD4+/CD8+higher than that of control group ( P <0.05).(2) The incidence of infection:the treatment group had 16 cases of infectious diseases (30.77%), the control group had 18 cases of infectious diseases (37.50%), with a significant difference between the 2 groups ( t =2.021, P <0.05).(3) The survival time: in the treatment group, the median survival time was longer than that of the control group ( 12.9 months vs.11.9 months, P <0.05).Conclusion Thymalfasin could reduce the inci-dence of infection in advanced non-small cell lung cancer patients , as well to reduce mortality due to infection rate , and im-prove the median survival time of patients .
Keywords：Non-small cell lung canceradvancedThymalfasinImmune therapyInfection
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 683-685 )