Clinical characteristics of chronic obstructive pulmonary disease and obstructive sleep apnea syndrome patients and central respiratory effects on positive pressure ventilation treatment
LU Fen
XIAO Guihua
CHENG Changhao
Abstract：Objective To observe the clinical features of chronic obstructive pulmonary disease ( COPD ) patients with obstructive sleep apnea syndrome ( OSAS) , and to explore the therapeutic effect of positive pressure ventilation .Methods There were 100 patients with COPD , including COPD with OSAS of 48 cases as the observation group , the patients with COPD of 52 cases as the control group;and the clinical characteristics of monitoring results of routine lung function , respirato-ry sleep were compared between the 2 groups; the observation group were treated by positive pressure ventilation , and ob-served the clinical effect of the treatment of patients with after 6 weeks of treatment .Results Compared with the control group, observation group patients'mass were larger than control group , [(61.4 ±7.1 kg) and (72.1 ±8.8 kg)], one second expiratory volume/vital capacity (FEV1/FVC), arterial partial pressure of oxygen( PaO2), oxygen saturation (SaO2) were decreased( P <0.05), partial pressure of carbon dioxide( PaCO2) and pH value had no significant difference ( P >0.05). Respiratory sleep monitoring results shows that , compared with the control group , the observation group sleep latency , hypo-xemia was obvious , respiratory disorder , in addition to total sleep time ( TST) , other indexes of the differences were statisti-cally significant ( P <0.05).The central response to hypoxia was increased after treatment in the observation group ( P <0.05), while no significant change in high carbon dioxide reactivity ( P >0.05).Conclusion The positive pressure ventila-tion treatment can eliminate apnea , improve sleep quality , improve the oxygen partial pressure , and improve the prognosis of the patients .
Keywords：Chronic obstructive pulmonary diseaseObstructive sleep apnea syndromePositive pressure ventilationClinical characteristics
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 677-679 )