Clinical features of neonatal myocarditis and the changes of serum levels of interleukin-6, tumor necrosis factor alpha
LI Xingchao
WANG Qian
XIE Jijian
LI Tao
Abstract：Objective To analyse the clinical characteristics of neonatal myocarditis , and to explore the changes of serum interleukin-6 (IL-6), tumor necrosis factor-α(TNF-α) levels.Methods From 2007 May to 2013 February, 85 cases of patients with myocarditis were enrolled , they were divided into acute period subgroup with 53 cases, recovery subgroup with 32 cases, over the same period, 50 cases of healthy infants were enrolled as control group .Observation of clinical manifesta-tion, electrocardiogram , chest X-ray features and myocardial enzymes , serum virus antibody test results in 85 cases of newborn children with myocarditis;using enzyme linked immunosorbent assay ( ELISA) test for the detection of serum IL-6, TNF-αlevels, and compared among the 3 groups.Results Viral myocarditis children's main clinical manifestations including poor mental reaction, pale, shortness of breath, cyanosis, milk refusal, low heart sound blunt, restlessness, fever, diarrhea;elec-trocardiogram showed atrioventricular block in 38 cases (44.7%), chest X-ray film showed increased in 59 cases (69.4%);heart color ultrasound showed 35 cases with congenital heart disease (41.2%), including 26 cases of atrial septal defect, 9 cases of ventricular septal defect .Detection of abnormal myocardial enzymes was found in all of the children , virus antibody test was positive in 56 patients (65.9%), mainly were Coxsackie B virus, adenovirus and cytomegalovirus (CMV).Acute period subgroup ’ s serum IL-6, TNF-αlevels were significantly higher in recovery period subgroup and healthy control group , the difference was statistically significant among groups ( t =20.573, 14.631, P <0.05); and the recovery period of sub-group and the healthy control group was showed no significant difference ( t =1.312,1.384, P >0.05).Conclusion Neo-natal myocarditis has its own clinical manifestation , detection of serum IL-6, TNF-αhas great significant for the diagnosis and treatment of the disease .
Keywords：MyocarditisneonatalClinical characteristicsInterleukin-6Tumor necrosis factor-α
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 668-670 )