The effect of valsartan on adiponectin and vascual r en dothelial function in coronary artery disease
ZOU Yan
LIU Cuizhong
WANG Yangui
Abstract：Objective To investigate the effects of valsartan on adiponectin and endothelial function in patients with coronary heart disease .Methods Forty patients were randomly divided into 2 groups, the conventional treatment group of 20 cases treated with aspirin and tartaric acid metoprolol (Betaloc), valsartan group of 20 cases were given conventional treatment and valsartan .Before and 8 weeks after treatment , ultrasonic Doppler examination were performed for the determination of bra-chial artery flow mediated vasodilation ( FMD) before and after treatment , and patients'plasma adiponectin levels and nitric oxide (NO) level.Results Compared with before treatment, the conventional treatment group of the brachial artery diameter , FMD, NO, adiponectin level had no significant changes ( P >0.05), valsartan group except brachial arteries , other indexes were significantly elevated ( P <0.05, P <0.01).Compared with the conventional treatment group , after treatment, valsar-tan group's FMD, adiponectin, NO levels were significantly increased ( P <0.05, P <0.01).Before and after treatment, blood pressure levels in the 2 groups had no obvious change .FMD and adiponectin levels (β=0.308, P <0.05) and NO (β=0.417, P <0.05) were positively correlated.Conclusion The valsartan could improve endothelial function in patients with coronary heart disease by increasing adiponectin levels .
Keywords：ValsartanCoronary heart diseaseAdiponectinEndothelial functionNitric oxide
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 665-667 )