Research on the clinical effect of Chaiyujisheng decoction in dealing with hyperprolactinemia with late menstruation

ZHANG Yunna; JIN Zhe; SUI Conglu; TONG Qing; XU Cui; XU Cai; LIN Tong

doi:10.3969/j.issn.1671-6450.2014.06.022

Abstract：Objective To observe the effect of Chaiyujisheng decoction week therapy with soothing the liver and in-vigorating the kidney in the treatment of liver and kidney deficiency type hyperprolactinemia menstruation , and to explore its mechanism of action .Methods 60 cases of hyperprolactinemia late menstruation patients , randomly divided into treatment group (Chaiyujisheng decoction) and control group (bromocriptine) with 30 cases in each group.To observe the clinical cur-ative effect before and after treatment , TCM symptoms, blood prolactin ( PRL) and the association between hormone ( E2 , LH) , and compare the effects of the two therapy .Results Compared with before treatment , index scores of the 2 groups after treatment were improved, the difference was statistically significant ( P <0.05);treatment group in improving the menstrual cycle and symptom , breast distending pain , menstrual distending pain in the lower abdomen and other symptoms are signifi -cantly better than the control group ( P <0.05), the treatment group the total symptom score index was 81.0%, control group 33.0%.Compared with before treatment, the 2 groups after treatment PRL, P, LH, E2 levels decreased ( P <0.05), and the treatment group E2 levels significantly better than the control group ( P <0.05), there were no significant differences in FSH levels in the 2 groups before and after treatment ( P >0 .05 ) .The 2 group total effectiveness have statistics signifi-cance (86.7%vs.73.3%, P <0.05).Conclusion It demonstrated that the Chaiyujisheng decoction week therapy with soothing the liver and invigorating the kidney in treatment of hyperprolactinemia is safe , effective .