Clinical follow up study on efficacy of local hyperthermia combined with oxaliplatin, docetaxel, 5-fluorouracil in treatment of advanced gastric cancer
LU Qinggang
MOU Anna
ZHU Li
ZHANG Tao
Abstract：Objective To explore the clinical efficacy of local hyperthermia combined with oxaliplatin (L-OHP), do-cetaxel (DXL) and 5 fluorouracil (5-FU) in the treatment of advanced gastric cancer .Methods Selected from 2009 Septem-ber to 2011 October hospitalized patients of gastric cancer (85 cases), they were randomly divided into observation group (44 cases) and control group (41 cases).Patients in the control group treated by L-OHP+DXL+5 FU with 4 cycles of chemo-therapy, the observation group based on the same chemotherapy , meanwhile synchronous give local thermotherapy , after thera-py, follow-up 24 months, compared the 2 groups'curative effect and 24 months survival rate .Results (1) 2 months after the end of chemotherapy, the observation group total effective rate was 79.5%,clinical benefit rate was 95.5%,KPS score was (77.5 ±5.2)points,these indexes were higher than that of the control group [61.0%,85.4%and (75.2 ±5.5)points],and there was significant difference in KPS score ( P <0.05).(2) During the chemotherapy, drug toxicity type and occurrence of the 2 group were similar;there was no significant difference ( P >0.05).(3) The observation group and the control group's 24 months after chemotherapy survival rate were 43.2%and 34.2%respectively, no significant difference were found (χ2 =0.730, P =0.393), the average survival time was 20.068 (95%CI 19.764-20.373) months, 18.767 (95%CI 18.379-19.155) months, the cumulative survival probabilities were 0.547 ±0.017 and 0.477 ±0.019 respectively, the differences were statistically significant ( t =25.878, P =0.000,χ2 =19.926, P =0.000).Conclusion Combination of local hyper-thermia and L-OHP+DXL+5-FU regimen in treatment of advanced gastric cancer can play a synergistic role in improving life quality with tumor , and prolonging the survival durations .
Keywords：Advanced gastric cancerLocal hyperthermia therapyOxaliplatinDocetaxel5-fluorouracilFollow-up research
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 597-600 )