Effect of non-invasive positive pressure ventilation on plasma hs-CRP and NT-pro BNP in acute exacerbations of AE-COPD combined with pulmonary heart disease
FU Huiwen
XU Yunduo
SUN Tao
GUO An
Abstract：Objective To investigate the effect of non invasive positive pressure ventilation on plasma high sensitive C-reactive protein(hs-CRP) and N-terminal pro brain natriuretic peptide (NT-pro BNP) of acute exacerbations of chronic ob-structive pulmonary disease ( AECOPD) combined with pulmonary heart disease .Methods 80 cases of patients with pulmo-nary heart disease with AECOPD were randomly divided into 2 groups, 40 cases in each group, the control group received rou-tine treatment of anti infection and cough , expectorant , based on these treatment , the observation group combined the use of noninvasive positive pressure ventilation therapy , 10 d as 1 course of treatment , compared 2 groups'before and after treatment of blood gas analysis and plasma hs-CRP and NT-proBNP levels.Results Observation group after treatment , blood pH, PaO2, PaCO2 and SaO2 were (7.42 ±0.06), (70.02 ±3.66) mm Hg, (61.34 ±4.31) mm Hg and (92.55 ±4.83)%respectively, compared with those before treatment of (7.20 ±0.05), (48.67 ±3.48) mm Hg, (88.94 ±4.43) mm Hg and (79.83 ±3.64)%, these indexes was significantly improved ( P <0.05), and the degree of improvement is better than the control group after treatment of (7.28 ±0.05), (58.90 ±3.74) mm Hg, (72.66 ±4.43) mm Hg and (81.32 ±4.17)%(P <0.05);the observation group after treatment , the plasma hs-CRP and NT-proBNP levels were (7.36 ±1.02) ng/L and (112.80 ±10.03) ng/L, these indexes were lower than before treatment (28.10 ±2.36) ng/L and (280.73 ±13.23) ng/L, these indexes was significantly reduced ( P <0.05), and the extent of decrease was better than the control group after treatment of (14.44 ±1.63) ng/L and (175.61 ±10.87) ng/L ( P <0.05).Conclusion Noninvasive positive pressure ventilation in the treatment of AECOPD with pulmonary heart disease has significantly curative effect , it can significantly re-duce the plasma hs-CRP and NT-proBNP level, and has good clinical application value .
Keywords：Non invasive positive pressure ventilationChronic obstructive pulmonary disease acute exacerbationPulmonary heart diseaseHigh sensitive C-reactive proteinN-terminal pro brain natriuretic peptide
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 590-591,596 )