The effect of rosuvastatin calcium combined with clopidogrel hydrogen sulfate on carotid intima media thickness in patients with hyperlipidemia
WEN Lei
LI Hui
WANG Li
Abstract：Objective To observe the effect of rosuvastatin calcium combined with clopidogrel on blood lipid , serum tumor necrosis factor-α(TNF-α), interleukin-1 (IL-1), interleukin-6 (IL-6) level and carotid artery intima-media thickness (IMT),as well as the effect on plaque area ,in elderly patients with hyperlipidemia .Methods 134 patients with hyperlipi-demia were randomly divided into the observation group of 70 cases, with rosuvastatin calcium 10 mg, clopidogrel hydrogen sulfate 75 mg orally, 1 times a day;64 patients in control group only received clopidogrel hydrogen sulfate , 75 mg orally, 1 times a day.Before treatment, after 12 weeks of treatment, 2 groups of patients'total cholesterol (TC) were measured,total triglyceride ( TG) , high density lipoprotein cholesterol ( HDL-C) , low density lipoprotein cholesterol ( LDL-C) , serum TNF-α, IL-1, IL-6 and IMT, plaque area were measured and recorded .Results Before treatment, there were no significant differ-ences of 2 groups'TC, TG, HDL-C, LDL-C, TNF-α, IL-1, IL-6, IMT, plaque area, ( P >0.05).Compared with those be-fore treatment, 12 weeks after the treatment, control group's TG, TC, TNF-α, IL-1,IL-6 were decreased ( P <0.05), and LDL-C, HDL-C, IMT and plaque area had no significant changes ( P >0.05);observation group's TG, TC, LDL-C, TNF-α, IL-1, IL-6 were decreased, IMT and plaque area were reduced, HDL-C increased ( P <0.05).After 12 weeks of treat-ment, compared with the control group , the observation group's TG, TC, LDL-C and TNF-α, IL-1, IL-6 levels were signifi-cantly lower ( P <0.05), HDL-C levels were significantly elevated ( P <0.05), IMT, plaque area was significantly re-duced ( P <0.05).Conclusion Rosuvastatin calcium combined with clopidogrel hydrogen sulfate could significantly de -crease the blood lipid and inflammatory factor level in patients with hyperlipidemia ,reduce the carotid intima-media thickness and plaque area .
Keywords：Rosuvastatin calciumClopidogrel hydrogens sulfateHyperlipidemiaCarotid artery intima-media thicknessInflammatory factors
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 579-581 )