The relevance of serum levels of amyloid A protein and changes of cystatin C in acute ischemic cerebrovascular di-sease
ZHAN Qianli
MENG Fanjun
TIAN Xiaoyan
Abstract：Objective To observe acute ischemic stroke patients serum amyloid A (SAA) and cystatin C (CysC) levels, to explore the relationship between the pathogenesis of acute ischemic stroke and SAA , CysC.Methods Collected pa-tients with acute ischemic stroke in 66 cases as the observation group;20 cases of healthy people as healthy control group .The 2 groups were collected venous blood , using the method of ELISA for determination of serum SAA , CysC levels .The observa-tion group in the hospital within 24 h were underwent National Institute of Health Stroke Scale ( NIHSS) score evaluation , and the correlation between SAA , CysC level and NIHSS score were analyzed .Results Observation group's serum level of SAA [(2.293 ±1.067) mg/L vs.(0.405 ±0.189) mg/L],CysC [(1.924 ±0.693) mg/L vs.(0.681 ±0.173) mg/L] was significantly higher than the control group ( t =13.679, t =13.271, P <0.05).The observation group according to NIHSS score were divided into light sub-group with 17 cases (<4 points), and medium subgroup of 45 cases (4~15 points), se-vere subgroup with 4 cases (>15 points);3 subgroups'SAA, CysC levels showed significant differences ( P <0.05), re-spectively, as severe subgroup >medium subgroup >light subgroup.Observation group's serum SAA, CysC levels were pos-itively correlated with NIHSS score ( r =0.981, r =0.934, P <0.05).Conclusion Acute ischemic cerebral stroke patients whose serum SAA , CysC levels were significantly higher than those of healthy people , the serum SAA and CysC level were positively correlated with NIHSS score .
Keywords：StrokeacuteischemicSerum amyloid A proteinCystatin CNational Institute of Health Stroke Scale score
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 573-575 )