Clinical effect of coaprovel in the treatment of elder patients with isolated systolic hypertension

LUO Yingchao; CHEN Guoqiang; Z HANG Jiniqa ng

doi:10.3969/j.issn.1671-6450.2014.06.007

Abstract：Objective To investigate the clinical effect of coaprovel in the treatment of elder patients with isolated systolic hypertension ( ISH) .Methods From January 2010 to December2012 ,elderly patients meets the standard of diagnosis and treatment of isolated systolic hypertension (78 cases) were randomly divided into 2 groups, observation group were re-ceived the Abono treatment (39 cases, 4 cases were excluded), control group were received enalapril and hydrochlorothiazide combination therapy (39 cases, 3 cases were excluded).Clinical curative effect, blood pressure, pulse pressure and electro-lyte changes and adverse reactions of 2 groups of patients were recorded and compared .Results Patients in the observation group's total effective rate was 91.4%(32/35), and in control group was 91.6%(33/36), there were no significant differ-ences ( P >0.05).2 groups of patients with systolic pressure , diastolic pressure and pulse pressure increased along with the time increased, but the 2 groups'2,4, 6, 8 weeks intra -group comparison revealed no significant difference ( P>0.05);compared with before treatment , after 2,4,6,8 weeks treatment, three indicators of the 2 groups were significantly improved (except DBP after 2 weeks in control group, P <0.05).Heart rate of the2 groups of patients also had no obvious change (P >0.05).After treatment, except the control group's blood K+level was mild declined ( P <0.05), before and after treatment, electrolyte, liver and kidney function of the 2 groups had no significant changes ( P >0.05).The observation group's incidence of adverse events was 5.7%(2/35), the control group's incidence of adverse events was 8.3% (3/36), the difference had no statistical significance ( P >0.05).Conclusion In the treatment of elder ISH patients ,coaprovel can effectively control blood pressure,had great curative effects ,the adverse reactions rate was low.Hence ,it was worthy of clinical promotion.