The relationship between the polymorphism of PPARγC161→T,α-adducin Gly460Trp and essential hypertension
ZHANG Yang
ZOU Xiaoyi
LIU Shuangjiang
SUN Qiang
DING Lijun
HAO Jia
ZHAO Jun
Abstract：Objective To investigate the relationship between peroxisome proliferator activated receptor gamma (PPARγ) C161 →T,α-adducin gene Gly460Trp polymorphism and essential hypertension (EH).Methods Patients with essential hypertension (hypertension group) were 262 cases, and 270 normal persons (control group) were enrolled in the re-search, using polymerase chain reaction restriction fragment length polymorphism of loci PPARγgene and α-adducin gene Gly460Trp analysis, analyzed the 2 kinds of gene polymorphism frequency and compared between them .Results In hyperten-sion group, PPARγC161 → T genotype distribution as follows:10 cases of type TT (3.82%), type TC in 70 cases (26.72%), type CC in 182 cases (69.46%), the T allele was 90 cases (17.18%), C allele was 434 cases (82.82%);In healthy control group, distribution of PPARγC161→T gene type were TT type in 17 cases (6.30%), type TC in 119 ca-ses (44.07%), type CC in 134 cases (49.63%), the T allele was 153 cases (28.33%), C allele in 387 cases time (71.67%), compared the difference of distribution between the 2 groups showed statistically significant ( P <0.05).Hyper-tension group alpha-adducin Gly460Trp genotype distribution as follows:GlyGly type in 57 cases (21.76%), type GlyTrp in 129 cases (49.23%), type TrpTrp in 76 cases (29.01%), the Gly allele was 243 cases (46.37%), the Trp allele was 281 cases ( 53.63%); healthy controls 'α-adducin Gly460Trp genotype distribution as follows:GlyGly type in 63 cases (23.33%), type GlyTrp in 124 cases (45.93%), type TrpTrp in 83 cases (30.74%), the Gly allele was 250 cases (46.30%), the Trp allele was 290 cases (53.70%), no statistically significant difference of distribution between the 2 groups were found ( P >0.05).Conclusion Chinese population with PPARγC161→T gene polymorphism correlated with essential hypertension;no correlation between α-adducin gene Gly460Trp polymorphism and essential hypertension .
Keywords：HypertensionessentialPeroxisome proliferator activated receptor gammaα-adducinGene polymorphis
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 563-566 )