The effects of TP-5 resuscitating serious traumatic hemorrhagic shock on immune function in rats
SHAO Zhongda
ZHANG Jianxin
CHEN Shuohua
CAI Lisong
ZHANG Xiaoping
CHENG Aiguo
Abstract：Objective To investigate the influence of TP-5 on immune function of rats with severe traumatic hemor-rhagic shock.Methods 54 healthy male SD rats were randomly divided into three groups , the control group( n =6), severe traumatic hemorrhagic shock model (model group, n =24), TP-5 resuscitation group(TP-5 group, n =24), in recovery after 12 ( T1 ) , 24 ( T2 ) , 48 ( T3 ) , 72 ( T4 ) each time window picked up venous blood , used flow cytometry to measure the con-tent of T lymphocyte subsets and used ELISA to measure SIgA content within intestinal mucus .Results Model group and TP-5 group's mortality rate were 4.17%(1/24), the difference was not statistically significant ( P >0.05).Compared with the control group, model group T1-4 of CD4+,CD4+/CD8+,SIgA levels were significantly decreased ,CD8+was significantly higher (P <0.01, P <0.05); compared with the model group, TP-5 group with prolonged recovery, the index gradually recov-ered, significantly better than the model group ( P <0.01, P <0.05).Conclusion Combined TP-5 early resuscitation of severe traumatic hemorrhagic shock in rats immune function have a protective effect .
Keywords：Shocktraumatic hemorrhagicImmune functionThymopentinSecretory immunoglobulin ARats
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 502-505 )