Effects of amlodipine combined with valsartan on the blood pressure, endothelin-1 and NO in elderly patients with hypertension

LIANG Dexian; LI Qingjun; CHENG Kangrong

doi:10.3969/j.issn.1671-6450.2014.05.009

Abstract：Objective To observe the effect of amlodipine combined with valsartan on the blood pressure ,endothelin (ET-1) and NO in elderly patients with hypertension .Methods Forty cases of elderly patients with hypertension were ran-domly divided into two groups of 20 cases in each group .Observation group were given amlodipine and valsartan combination therapy, the control group only received valsartan , compared two groups'blood pressure,ET-1,NO and vascular elasticity in-dex changes.Results Two groups 2,4,6,8 weeks after treatment, compared with pre-treatment, blood pressure were dropped, and the observation group decreased more significantly than in the control group ( P <0.05);compared with before treatment, 2 groups after 8 weeks of treatment, ET-1, NO were improved ( P <0.05),and observation group significantly im-proved compared with the control group ( P <0.05);in both groups after 8 weeks of treatment,arterial elastic index(C1,C2) increased than those before treatment , and observation group significantly higher than the control group ( P <0.05);after 8 weeks of treatment, in two groups pulse ware velocity(PWV) and ankle -brachial index were better than those pre-treatment, observation group was better than control group ( P <0.05).2 groups'incidence of adverse reactions was showed no signifi-cant difference ( P >0.05).Conclusion It's demonstrated that the amlodipine combined with valsartan had good efficacy in elderly hypertensive patients the antihypertensive effect is obvious ,ET-1 were significantly decreased ,NO were significantly in-creased,vascular elastic function were improved .