The effect of thrombus aspiration plus tirofiban on myocardial reperfusion in patients with acute myocardial infarc-tion treated by primary percutaneous coronary intervention
CHEN Yushan
XIE Jinhong
LUO Minghua
QIU Chengjie
WANG He
DONG Wenjie
ZONG Yonghua
GUAN Huaimin
Abstract：Objective To investigate efficacy and safety of thrombectomy and given tirofiban through catheter in acute ST-segment elevation myocardial infarction (ASTEMI ) patients who were underwent percutaneous coronary intervention (PCI).Methods From August 2011 to August 2013, select 57 admitted ASTEMI patients, they were randomly divided into two groups , the treatment group with 30 patients ( intravenous injected tirofiban , PCI with intraoperative thrombus aspiration , and intracoronary tirofiban injection ) , the control group with 27 patients ( treated with PCI alone , only intravenous injected tirofiban) .The coronary TIMI grade were observed immediately after intervention , as well as before and after intervention's isoenzyme of creatine kinase (CK-MB) peak; after 1.5 h ECG ST-segment resolution index (STR)≥50% rate; compare postoperative one week and three months'changes of left ventricular ejection fraction ( LVEF) and left ventricular end-diastolic diameter ( LVEDD);comparing two groups of patients bleeding rate and the incidence of main adverse cardiovascular events (MACE).Results Coronary angiography TIMI with grade of 3's proportion,1.5 h after intervention's electrocardiogram STR≥50%rate in the treatment group was higher than control group ( P <0.05 ); treatment group's time to peak cardiac enzyme CK-MB significantly lower than the control group ( P <0.05); cardiac ultrasound examination after 1 week and 3 months of intervention showed that 2 group's LVEDD, LVEF were significantly different ( P <0.05).There were no significant differ-ence of postoperative bleeding event and MACE in the two groups ( P >0.05).Conclusion Emergency PCI thrombus as-piration and intraoperative through the coronary give tirofiban can increase the level of myocardial perfusion and reduce the number of necrotic myocardium and improve short -term prognosis,with obvious therapeutic effect and good safety .
Keywords：Myocardial infarctionacutePercutaneous coronary interventionThrombus aspirationTirofiban
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 456-459 )