FOLFOX4 neoadjuvant chemotherapy in eldelr yp atients with lowe r colorectal cancer
LIAN Bo
SONG Chun
LI Pen-glie
Abstract：Objective To observe and discuss toxicity and short&long term efficacy of FOLFOX 4 neoadjuvant chem-otherapy scheme in treatment of elderly patient with limited lower rectal carcinoma .Methods Limited lower colorectal cancer elderly patients were selected from January 2008 to January 2011 (68 cases), they were treated as research subjects and were randomly divided into observation group and control group , 34 cases in each group .Observation group treated with FOLFOX 4 neoadjuvant chemotherapy after surgical treatment , control group directly underwent surgical treatment .Cases'tumor progres-sion in patients with chemotherapy before and after chemotherapy were recorded , compared two groups sphincter preservation , near and long-term outcome .Results Neoadjuvant chemotherapy observation group total effective rate was 61 .76% ( 21/34), decreased tumor staging after chemotherapy .Observation group and control group sphincter preserving surgery rates were 93.55%and 61.76%, and the difference was statistically significant ( P <0.05);observation group and control group after 2 -year cumulative survival rate's (0.605 ±0.079 vs.0.412 ±0.084) difference was statistically significant ( P <0.05). Observation group had a higher incidence of constipation , diarrhea, nausea, vomiting, neutropenia and other adverse reac-tions, including three cases ( 8.82%) intolerance terminated chemotherapy .Conclusion Using preoperative neoadjuvant chemotherapy with FOLFOX4 significantly improved the limited of colorectal cancer staging , improve sphincter preservation surgery and postoperative short , long-term effect.
Keywords：Colorectal cancerlowerNeoadjuvant chemotherapyFOLFOX4Sphincter preservationSurvival rate
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 444-447 )