Influence of clioquinol on experimental cerebral hemorrhage in rats with ceruloplasmin expression
CHEN Yanli
WANG Gaiqing
YIN Yongfeng
ZHAO Rui
Abstract：Objective To study the effect of clioquinol on the expression of ceruloplasmin in experimental cerebral hemorrhage ( ICH) rats.Methods 48 Wistar rats were randomly divided into 2 groups: control group and the intervention group with each group of 24 rats, using stereotactic injection of collagenase preparation ICH model to the caudate nucleus of rats, after molding success the intervention group were given clioquinol 50 mg /kg orally every 12 h;intragastric saline control group.From each of 2 groups, six rats decapitated at different time points after 1, 3,7,14 d, using immunohistochemical stai-ning and real-time PCR detection of Cp .Results ICH model after preparation , two groups with time Cp positive expression was significantly increased in the first seven days of the peak;compared with the control group , the intervention group within the brain tissue of rats in the first Cp day showed no significant difference ( P >0.05), the expression at 3-14 d were higher ( P <0.05).2 groups'Cp mRNA expression levels peaked at 7 days, and the first 3,7,14 d were higher than the first day expression level ( P <0.05).Compared with the control group , the intervention group 3,7,14 day Cp mRNA expression lev-els were higher ( P <0.05).Conclusion CQ adjust cerebral hemorrhage by regulating the expression of ceruloplasmin in brain tissue, brain tissue may accelerate the removal of iron ions and thus play a protective role in the brain .
Keywords：Chloroiodide quinolineCerebral hemorrhageCeruloplasminRats
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 392-394 )