Impact of dezocine combined with fentanyl analgesia on pain caused by substances in elderly patients undergoing total joint replacement
ZUO Ling
LIU Chunsheng
WANG Meiling
LV Yanxia
LIANG Li
Abstract：Objective To observe the efficacy of the combination of dezocine and fentanyl , and to investigate the effect on serum 5-hydroxytryptamine (5-HT) and P substance (SP).Methods Ninety ASA I or II patients undergoing elec-tive total hip replacement operation in general anesthesia randomly divided into 3 groups, 30 cases in each group.Group A:the fentanyl group;Group B:the combined groups;Group C:the dezocine group .10 min before finish the surgery , 3 groups were analgesia intravenous analgesia pump liquid 5 ml as load, intravenous access surgery PCA pump into conscious extuba-tion.Analgesic solution preparation:A group dezocine 0.5 mg /kg, group B for fentanyl 10μg /kg, C group dezocine 0.25 mg /kg +fentanyl 5μg /kg for the land , in both groups of pumps were added with ondansetron 8 mg and saline formulated into a total of 100 ml, background infusion rate 2 ml /h, PCA volume 0.5 ml, lockout time 15 min.Using the VAS score and Ramsay score were evaluated after 2,6,12,24 and 48 h analgesia and sedation level;measured before anesthesia , 12,24,48 h serum concentrations of 5-HT and SP;recorded within 48 h after the occurrence of adverse reactions .Results Compared with the postoperative 2 h, after 24,48 h, VAS score and Ramsay score in three groups were decreased ( P <0.05); and com-pared with group A and B, group C after 2,6,12,24 h's Ramsay score was significantly higher ( P <0.05).Compared with the previous anesthesia , patients in three groups 12,24,48 h's serum 5-HT and PS concentration was increased ( P <0.05);Compared with group A, group C after 12,24,48 h's 5-HT and SP serum concentrations were significantly lower ( P <0.05);compared with group B , group C's 5-HT and SP concentrations were significantly decreased ( P <0 g.05 ) .Compared with group A and group B, group C's nausea, vomiting, respiratory depression, dizziness occurred significantly reduced (group A of 16.7%, group B of 26.7%, group C of 6.7%, P <0.05).Conclusion Dezocine combined with fentanyl on controlled intravenous analgesia joint replacement surgery can effectively relieve postoperative pain , suppress and SP after 5-HT concen-tration, poor reactions occur less than single usages , worthy of clinical application .
Keywords：DezocineFentanylControlled intravenous analgesia5-hydroxytryptamineP substance
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 385-388 )