Early diabetic nephropathy 1,25-(OH)2D3 and changes of inflammatory factors and effect of calcitriol capsules
DU-AN Xiaoxing
CHANG Yongli
ZHI Shuqing
Abstract：Objective To observe the effects of vitamin D metabolites 1,25-dihydroxy vitamin D3[1,25-(OH)2D3] on early diabetic nephropathy (DN) in patients with inflammatory factors TGF-β, TNF-α, IL-6, hs-CRP level.Methods 150 patients with type 2 diabetes, in which 60 patients with diabetes alone as the DM group , 90cases of early DN as DN group.DN group was randomly divided into sub-treatment group and sub-control group with each group of 45 cases.Control subgroup received conventional treatment , treatment subgroup received conventional therapy +calcitriol capsules , after 3 months of treatment 1,25-(OH)2D3,24 h urinary protein and related inflammatory factors changes were compared among groups.Results Before treatment, DN group's 1,25-(OH)2D3 levels lower than the DM group ( P <0.05);TGF-β, TNF-α, IL-6, hs-CRP, 24 h urinary protein, SCr levels were higher than the DM group ( P <0.05); after treatment, treatment subgroup's TGF-β, TNF-α, IL-6, hs-CRP levels and 24 h urinary protein quantitative lower than before treatment ( P <0.05),1,25-(OH)2D3 levels increased compared with the previous ( P <0.05).Poor control and treatment subgroup reac-tion rate difference was not statistically significant (11.11%vs.11.11%, P >0.05).Conclusion Early DN patients'1, 25-( OH) 2 D3 deficiency , levels of inflammatory cytokines increased , complement calcitriol capsules can improve inflammatory state.
Keywords：Diabetic nephropathy125-dihydroxy vitamin D3Inflammatory factorsCalcitriol capsules
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 378-380 )