Therapeutic effect of human umbilical cord blood stem cells on ischemic heart disease

YANG Huaqiang; LI Hong; LI Yuling; QING Jun; BAO Hongxia; LV Xiaojuan; WANG Jianing; XIAO Junhui

doi:10.3969/j.issn.1671-6450.2014.04.010

Abstract：Objective To observe the clinical efficacy and safety of cord blood stem cell transplantation for ischemic heart disease treatment .Methods Thirty cases of patients with ischemic heart disease with coronary multi-vessel disease after drug treatment is generally ineffective , not suitable for interventional therapy and coronary artery bypass surgery , they received treatment of using of stem cells from human cord blood through the coronary interventional angiography transplantation therapy . Review the ECG and laboratory indicators , observed treatment safety , echocardiographic evaluation of cardiac function , and performed SF-36 Health Questionnaire to evaluate the quality of life and clinical symptoms of patients and improvement of signs and adverse reactions before cord blood stem cells treatment , 3 and 6 months after treatment , respectively .Results After one week of umbilical cord blood stem cell therapy , clinical symptoms of 26 patients improved significantly , 3 and 6 months after surgery, left ventricular end-diastolic volume and left ventricular end-systolic significantly reduced than before therapy .Left ventricular ejection fraction was significantly improved compared with the preoperative ( P <0.05, P <0.01).SF 36 health scores revealed that , 3 months and 6 months after treatment , compared with pre-treatment physical function , exercise restric-tions and general health scores were significantly increased ( P <0.05, P <0.01), and after treatment, patients were fol-lowed up for 6 months, no treatment-related adverse reactions were observed .Conclusion Cord blood stem cells via coronary intervention can improve clinical symptoms and cardiac function in patients with ischemic heart disease in short -term, is a safe and effective treatment options .