The effects of Tongxinluoc apsule on myocardial mi crocirculation perfusion,cardiac function and electrophysiology of rabbist after myocardial inaf rction
XIONG Liang
HUANG Congxin
HUANG He
WANG Xi
KONG Bin
JIANG Xiaobo
DANG Song
Abstract：Objective To evulate the effects of Tongxinluo ( TXL) on myocardial microcirculation perfusion , cardiac function and cardiac electrophysiology of rabbits after myocardial infarction .Meth ods 24 New Zealand rabbits were randomly assigned into three groups: sham group ( n =8 ) , which underwent thoracotomy and pericardiotomy without coronary artery ligation, MI group ( n =8) and TXL group ( n =8), both of which underwent thoracotomy , pericardiotomy and the left ante-rior descending coronary artery was ligated to induce MI .TXL group were treated with TXL superfine powder 0.4 g· kg -1 · d-1 for 8 weeks after the operation , while the sham and MI groups were administered with normal saline for the same time as control.Myocardial microcirculation perfusion was tested by real time myocardial contrast echocardiography (RT-MCE) after 2 weeks and 4 weeks respectively .Cardiac function was studied using echocardiography ,and 90%of monophasic action poten-tial duration (MAPD90) of epicardium, midmyocardium and endocardium, transmural dispersion of repolarization (TDR), effective refractory period ( ERP) , and ventricular fibrillation threshold ( VFT) were measured at the infarct border zone ( MI group and TXL group) and corresponding zone (sham group) in vovoR. esutl s The myocardial microcirculation perfusion of the infarct related zone in TXL group was significantly improved than MI group , and A ×βwhich represented the myocardial blood perfusion increased markedly [after 2 weeks:(7.24 ±1.11) dB ×s-1 vs.( 10.66 ±1.23) dB ×s-1, P <0.05;after 4 weeks(7.23 ±0.81) dB ×s-1 vs.(11.12 ±1.73) dB ×s-1, P <0.05].To compared with MI group ,cardiac function was also significantly improved inTXL group after 8 weeks of MI ( FS:0.25 ±0.02 vs.0.3 ±0.02, P <00.5 ; LVEF:0.54 ± 0.04 vs.0.61 ±0.03, P <0.05), and TXL significantly shortened the MAPD90 of the 3 layers [MAPD90endo :(170.65 ± 7.64)ms vs.(159.01 ±5.48) ms, P <0.05;MAPD90mid: (169.34 ±6.35) ms vs.(160.32 ±5.46) ms, P <0.05;MAPD90epi:(167.16 ±5.72) ms vs.(156.74 ±4.43) ms, P <0.05),reduced the TDR [(7.72 ±2.83) ms vs.(4.95 ± 2.26) ms, P <0.05],and increased the ERP [(126.56 ±5.87) ms vs.(135.25 ±5.63) ms, P <0.05] and VFT [(28.63 ±6.21)V vs.(44.75 ±13.73)V, P <0.05].Conclusion TXL significantly improved the myocardial microcircu-lation perfusion of the infarct related zone and cardiac function after MI .TXL also had a significant impact on cardiac electro-physiology after MI, for its anti-arrhythmic effects.
Keywords：Myocardial infarctionMicrocirculation perfusionCardiac functionElectrophysiologyTongxinl uo cap-suleRabbit
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 331-335 )