Efficacy of three dimensional conformal radiotherapy combined with FOLFOX4 chemotherapy synchronously in treatment of postoperative malignant retroperitoneal lymph node metastasis carcinoma
LU Qinggang
MOU Anna
ZHU Li
Abstract：Objective To observe the clinical efficacy of three-dimensional conformal radiotherapy (3DCRT) syn-chronized with FOLFOX4 in treatment of postoperative peritoneal malignant cancer of lymph node metastasis .Methods 85 patients with retroperitoneal lymph node metastases after resection of gastrointestinal cancer surgery were randomly divided into concurrent chemoradiotherapy group (45 cases) and the chemotherapy alone group (40 cases), chemotherapy group used of FOLFOX4, concurrent chemoradiotherapy group using three -dimensional conformal radiotherapy with FOLFOX 4, the recent long-term efficacy and adverse reactions during treatment (3 months) and after the end of treatment (3 years) survival rate were compared.Results (1) Short-term effect: concurrent chemoradiotherapy group tumor control rate was 82.2%, KPS score was (83.0 ±5.9) points, which were significantly higher than the 62.5% in the chemotherapy group with (80.4 ± 5.2) points ( P <0.05).(2) Adverse reactions: radiation dermatitis, radiation-induced lung (trachea) inflammation were concurrent chemoradiotherapy group specific adverse reaction , incidence difference between the two group was statistically sig -nificant.Other adverse reactions were found no significant difference ( P >0.05).(3) The cumulative survival rate (0.258 ±0.013), mean survival months (26.867 ±0.214) in chemoradiotherapy group were significantly higher than in the chemo -therapy group (0.137 ±0.012), (21.550 ±0.251) ( P <0.05).Conclusion Three-dimensional conformal radiotherapy with FOLFOX4 in treatment of postoperative chemotherapy retroperitoneal lymph node metastases of malignant cancer may im -prove survival, prolong survival, with a high near-term effect.
Keywords：Radiotherapythree-dimensional conformalFOLFOX4CancergastrointestinalMetastatic cancerlymph nodesSurvival rate
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 284-286,290 )