Effect of alpha lipoic acid combined with MIRE on the homocysteine level in diabetic autonomic neuropathy patients
ZHAO Qiaoling
LIANG Yuzhen
XIE Xinrong
YU Tianqiang
ZOU Wenbing
ZHAO Ni
Abstract：Objective To investigate the changes of serum homocysteine (Hcy) level in the diabetic autonomic neu-ropath ( DAN) patients after the intervention of alpha lipoic acid combined with monochromatic infrared photo energy (MIRE).Methods One hundred and thirty two patients of T2DM patients were divided into two groups : diabetic autonomic neuropathy(DAN) and non-autonomic neuropathy group (NDAN), 28 healthy subjects as control group.The cases of DAN plus hyperhomocysteinemia were treated with alpha lipoic acid and MIRE .Two weeks later, Hcy level was measured, and au-tonomic neuropathy improvement was evaluated by Neuropad .Results DAN group, DNAN group and the healthy control group's blood Hcy concentrations were (16.82 ±4.21)μmol/L, (12.42 ±3.06)μmol/L and (10.72 ±3.24)μmol/L, the differences among them were statistically significant ( P <0.05).After lipoic acid combined MIRE intervention , plasma Hcy levels in patients with high Hcy group decreased from (19.22 ±2.45)μmol/L to (16.10 ±2.68)μmol/L ( P <0.05), left foot Neuropad patch completely discolored time decreased from (24.81 ±7.60) min to (19.25 ±5.42) min ( P <0.05), right foot decreased from (23.44 ±7.40) min to (17.63 ±5.11) min ( P <0.05).Conclusion The level of serum Hcy in DAN patents was higher than that in NDAN patients , after treatment with alpha lipoic acid combined with MIRE can lower the Hcy level, and improve diabetic autonomic neuropathy function .
Keywords：Diabetic autonomic neuropathyHomocysteineMIREAlpha lipoic acidNeuropad
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 262-264 )