The impact of CRRT hemoperfusion MODS inflammatory response in patients with AKI
LI Bingxin
ZHOU Xiao bing
YANG Lin
XIA Jingbiao
Abstract：Objective To evaluate the effects of continuous renal replacement therapy (CRRT) combined with he-moperfusion (HP) on inflammation in multiple organ dysfunction syndrome (MODS) complicated with acute kidney injury (AKI) patients.Methods 40 MODS patients were randomly divided into combine group and CRRT group with 20 cases in each group.CRRT group with continuous veno -venous hemofiltration way of treating 72 h,combine group on the basis of CRRT treatment, carried out 2 h HP treatment every 24 h, detected patients generally condition (HR, MBP), renal function (BUN, SCr, CO2 CP), tumor necrosis factor-α(TNF-α), interleukin-1 (IL-1), interleukin-6 (IL-6), changes in interleu-kin-8 (IL-8).Results Compared with before treatment, the two groups after treatment reduces HR , and MBP was increased, and combine group better than CRRT group ( P <0.05), 2 groups'BUN, SCr were decreased, CO2 CP was increased ( P <0.05), whereas no statistically significant difference between the two groups was found ( P >0.05).After treatment 48, 72 h, serum TNF-α, IL-1, IL-6, IL-8 levels were decreased in both 2 groups ( P <0.05) compared with before treatment.Af-ter 72 h treatment, compared with CRRT group, these indexes in combine group were decreased more significantly ( P <0.05).Conclusion CRRT combined with hemoperfusion has better therapeutic effect of anti-inflammation in MODS compli-cated with AKI patients than CRRT treatment alone .
Keywords：Continuous renal replacement therapyMultiple organ dysfunction syndromeKidney injuryacuteIn-flammatory cytokines
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 253-255 )