The efficacy and safety of vildagliptin combined with metformin in the treatment of type 2 diabetes
YAN Zhaodan
HU Juping
TAO Dongqing
ZHOU Hongyan
Abstract：Objective To investigate the clinical efficacy of vildagliptin metformin in the treatment of type 2 diabetes and security analysis .Methods Selected from October, 2010 to October, 2012 admitted 120 patients with type 2 diabetes, they were randomly divided into 2 groups with each group of 60cases .In the control group , patients received metformin , treat-ment group were treated with metformin and vildagliptin , compared two groups of patients with clinical efficacy and adverse re-actions.Results Compared with before treatment, after treatment, two groups HbA1c, FPG, 2hPG, INS were significantly lower, and with elevated levels of GLP-1 ( P <0.01), and the treatment group compared with the control group , HbA1c, FPG, INS reduced, while GLP-1 levels increased more significantly ( P <0.01).2 groups were found no adverse reactions . Conclusion Metformin combined with vildagliptin in the treatment of type 2 diabetes , the clinical efficacy is superior to met-formin alone, and found no increase in adverse effects , while having a high clinical value .
Keywords：VildagliptinMetforminDiabetestype 2Efficacy
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 156-158 )