Pathologic and prognostic investigation of IgA dominant post infectious glomerulonephritis
WU Zhihui
TANG Xiao-tie
WANG Yan'e
LI Li
Abstract：Objective To determine the clinical and pathologic features of IgA dominant post infectious glomerulone -phritis ( PIGN ) , including its association with staphylococcal infections , underlying diabetes , frequency of progression to ESRD, and its pathologic spectrum on renal biopsy .Methods We retrospectively reviewed 25 renal biopsy of PIGN for the past 5 years, and analyzed the pathologic results of light microscopy , immunofluorescence microscopy and electron microsco-py.Their clinical outcomes were also summarized .Results All patients at the onset of clinical are S .aureus infections, among them, MSSA infection were 11 cases, MRSA infection in 14 cases.Renal biopsy showed that:acute phase PIGN 6 ca-ses with diffuse proliferative glomerulonephritis , recovery or subacute phase display mesangial cell proliferation .Immunofluo-rescence showed IgA deposition .Ultrastructural analysis showed that subcutaneous hump-shaped electron dense deposits .25 cases were treated with antibiotics theryapy , 12 cases were treated with antibiotics combined with methylprednisolone therapy , hemodialysis dependent on eight cases .16 patients discharged from hospital , six cases of complete remission , partial remis-sion in 10 cases;nine cases continued hospitalization , 5 patients died .Conclusion IgA dominant post infectious glomerulo-nephritis are associated with Staphylococcal infections .The diagnosis depends on IgA dominant or co-dominant immunofluores-cent staining and the presence of endocapillary proliferation , subepithelial electron dense deposits .
Keywords：IgA dominant post infectious glomerulonephritisIgAComplement systemPathology
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 149-152 )