Therapeutic effects of Wuling capsule on the prevention of depression after stroke and cognitive disorder

ZHANG Chenhao; ZANG Yanjing; LI Wengui; CHEN Liming; LI Hongxuan; LI Xiaoling; HAN Haiqing; FAN Yinping

doi:10.3969/j.issn.1671-6450.2014.02.009

Abstract：Objective To observe the curative effects of Wuling capsule ( WL) in preventing depression after cere-bral infarction ( DCI) and cognitive disorder .Methods Cerebral infarction 435 cases were randomly divided into two groups ( WL group and control group ) , based on the conventional treatment , WL group received oral WL capsules , 3 times a day;the control group was treated with placebo capsules , 3 times daily for all six weeks .Before and after treatment with 1st, 2nd, 4th, 6th weekends and at the end of 3 months, HAMD, MoCA, NIHSS score were assessed and observed the occurrence of depression .Results (1) The incidence of depression:Treatment at 2nd, 4th weekend, incidence rates of depression in WL group were lower than the control group , but the difference was not statistically significant ( P >0.05), and 6 weeks to 3 months after treatment , incidence rates of depression in WL group lower than the control group , and the difference was statisti-cally significant ( P <0.05).(2) HAMD score:2 groups after treatment increased than before treatment ( P <0.05), and in the WL group, at 2nd, 4th, 6th weekend and at the end of 3 months, the score were lower than the control group ( P <0.05).(3) NIHSS score:In addition to the first weekend , after treatment, the two groups'NIHSS score decreased than be-fore treatment ( P <0.05), and WL groups were better than the control group ( P <0.05).(4) MoCA Rating:after treat-ment, at 4th, 5th weekend and at the end of 3 months, the 2 groups'MoCA scores were elevated before treatment ( P <0.05), and WL groups were higher ( P <0.05).(5) Adverse reactions: two groups were not found serious adverse reac-tions.Conclusion It showed obviously effect of Wuling capsule on preventing DCI and neurological deficit .