Clinicopathologic analysis of Langerhans'cell histiocytosis:14 cases report
Luo Li
Huang Pei
Li Daoming
Liu Fengge
Wang Xiufang
Abstract：Objective To explore the clinicopathological features ,immunophenotypes ,diagnosis and differential diag-nosis of Langerhans'cell histiocytosis ( LCH) .Methods Analysis of the clinical features of 14 LCH cases were performed , HE staining and immunohistochemical techniques were applied to observe the pathological features ,the relative literatures were also reviewed.Results The patients consist of 11 males and 3 females ,aged from 9 months to 52 years, 13 cases of LCH were involved in bones(8 in skull, 3 in lower limb, 2 in vertebra), and 2 in skin .Light microscopy showed oval Langerhans cells (LCs) with irregular, grooved or folded nuclei, inconspicuous nucleoli, thin nuclear membranes, moderately abundant and slightly eosinophilic cytoplasm , accompanied with variable numbers of eosinophils infiltration .Immunohistochemical ex-pressions of CD1a and S-100 were positive in all cases, 12 cases expressed Langerin (2 cases didn't examined ),9 cases ex-pressed CD68, LCA,CD3 and CD20 were negative in all cases ,ki67 positive rate was 10%to 20%.Conclusion The clinical manifestation of LCH varies from a single system lesion to multi-system disease , and often occurs in bone , the diagnosis should be confirmed by pathological examination of biopsy;CD1a,S-100 and Langerin positive expressions in LCs have important sig-nificance for diagnosis and differential diagnosis of LCH .
Keywords：HistiocytosisLangerhans cellPathological analysis
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 63-64,73 )