Analysis of diagnostic value of ADA combined with IFN-γand LAM antigen for tuberculosis pleurisy
SHI Jian
ZHOU Lirong
SUN Baohua
WANG Xiaosheng
Abstract：Objective To explore the adenosine deaminase ( ADA) joint γinterferon ( IFN-γ) and lipoarabinoman-nan ( LAM) antigen diagnosis of tuberculous pleurisy .Methods Pleural effusion in 98 patients according to whether the na-ture of tuberculous pleural effusion into tuberculosis group (62 cases) and non-tuberculous group (36 cases).Comparative a-nalysis of two groups of patients with pleural effusion of serum ADA , IFN-γlevels and LAM positive rate and ROC curve to determine ADA combined IFN-γand LAM antigen for diagnosis of tuberculous pleurisy value .Results Tuberculous pleural effusion ADA and IFN-γlevels were significantly higher than non-tuberculosis group [(53.88 ±14.39) U/L, (496.82 ± 183.65) pg/ml vs.(15.07 ±12.36) U/L, (49.74 ±32.18 ) pg/ml, P <0.05];tuberculous and non-tuberculous group, the serum levels of ADA and IFN-γno statistically significant difference [(24.31 ±7.85) U/L, (47.88 ±8.35) pg /ml vs. (22.94 ±7.60) U/L, (45.62 ±7.74) pg/ml, P >0.05];tuberculous pleural effusion and serum LAM antigen positive rate was significantly higher than that of non-tuberculous group (64.52% and 74.19% vs.2.78% and 5.56%, P <0.05). Pleural effusion ADA joint IFN-γand LAM antigen in the diagnosis of tuberculous pleurisy high accuracy , the area under the ROC curve was 0.914 (95%CI 0.832-1.243).Conclusion Pleural effusion ADA joint IFN-γand LAM antigen detection for the diagnosis of tuberculous pleurisy with high accuracy , is worth promoting .
Keywords：PleurisytuberculousAdenosine deaminaseIFN-γLAM antigen
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 46-48 )