The relationship of NO, IGF-1 and S-100B protein in patients with Parkinson's disease
HUANG Rong
WANG Chong
Abstract：Objective To investigate the expression of NO , IGF-1 and S-100B in patients with Parkinson's disease. Methods Selected 112 cases of Parkinson's disease as the observation group , according to severity as mild in 37 cases,mode rate in 45 cases, 30 cases of severe.Select examination confirmed 70 cases of healthy adults as a healthy control group , serum NO, IGF-1 and S-100B level were tested and compared.Results In the observation group, serum NO, S-100B were signifi-cantly higher than healthy controls [ (5.92 ±1.45) μmol /L vs.(3.80 ±1.65) μmol /L, (80.57 ±16.20) ng /L vs. (67.54 ±22.41) ng/L], while IGF-1 levels were significantly lower than the healthy control group [(138.14 ±35.46) mg /ml vs.(168.73 ±39.75) mg /ml].As the lesions in observed group aggravation , NO, S-100B levels increased, IGF-1 level dropped, pairwise comparisons were statistically significant differences ( P <0.05).In observation group,NO, IGF-1 and S-100B level showed no correlation.Conclusion Parkinson's diseases patients'serum NO, IGF-1 and S-100B abnormal expression have a certain effect in promoting the progression of disease .
Keywords：Parkinson's diseaseNOIGF-1S-100B protein
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 40-41,58 )