The value of total cholesterol content of re ythrocyte membrane in diagnosis of acute coronary syndrome
LI Xiang-dong
WANG Xi n
WA NG Ancai
Abstract：Objectvi e To evaluate the diagnostic value of total cholesterol content of erythrocyte membrane (CEM) for acute coronary syndrome( ACS) .Methods 80 patients with chest pain in emergency department who were suspected of ACS were enrolled, including 55 males and 25 females;aged (53.6 ±7.2) years within 3 h of onset of chest pain and 3~6 h blood specimens were measured CEM , CK-MB, cTnI levels , combined coronary angiography and intracoronary ultrasound findings, referring to AHA/ACC criteria were divided into three groups:ACS group, stable angina pectoris (SAP) group and non-coronary heart disease (NCHD) groups.They were compared within 3 h and 3~6 h each group CEM, CKM-B , cTnI differences and observe CEM , CK-MB, cTnI combined detection of the ACS diagnostic value .Follow-up of patients with ACS compared cardiovascular events with and without cardiovascular events'CEM content differences .Results 80 cases of selected objects, diagnosis of ACS were 30 cases, SAP were 26 cases, NCHD 24 cases.ACS group CEM levels within 3 h and 3~6 h were significantly higher than SAP and NCHD group ( P <0.05).Within 3 h CK-MB, cTnI levels in all groups showed no significant difference ( P >0.05 ); 3 ~6 h, ACS group CK-MB, cTnI levels higher than SAP and NCHD group ( P <0.05).SAP and NCHD group at 3 h, 3 ~6 h each index showed no significant difference ( P >0.05).Combined detection of CEM, CK-MB, cTnI diagnosis of ACS sensitivity , specificity, positive predictive value and negative predictive value were 98.5%, 95.6%, 98.7%, and 99.3%, significantly higher than CK-MB, cTnI joint detection (89.8%, 87.5%, 90.3%, 91.5%), the difference was statistically significant ( P <0.05).CEM of cardiovascular events subgroup (12 cases) were sig-nificantly higher than the without cardiovascular events subgroup (18 cases), the difference was statistically significant (P<0.01).Conclusion CEM content can be detected at elevated markers of myocardial necrosis predicted before the occurrence of ACS, can make up for CK-MB, cTnI limitations of the ACS diagnosis , and CK-MB, cTnI joint detection can further im-prove the diagnostic value of the ACS .
Keywords：Total cholesterol content of erythrocyte membraneAcute coronary syndromeDiognosis
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 5-7,14 )