Study on T cell proliferation and TNF-α abnormalities in Lewis rats with active experimental autoimmune encephalomyelitis
LV Pei-yuan
SONG Chun-feng
KOH Chang-sung
INOUE Atsushi
Abstract：Objective To explore the relationship between T cell proliferation, serum tumor necrosis factor (TNF)-α abnormalities and clinical course of experimental autoimmune encephalomyelitis (EAE) in Lewis rats. Methods The rats of EAE were examined for the development of neurological signs of disease, T cell proliferation responses and TNF-α concentrations. Results There was an active T cell proliferation, and a marked TNF-α increase which paralleled with clinical onset in EAE. Conclusion Our studies suggest that T cell proliferation and increasing of TNF-α result in blood-brain barrier (BBB) breakdown and significant inflammatory cell recruitment which leads to EAE.
Keywords：Multiple sclerosisExperimental autoimmune encephalomyelitisT cell proliferationTumor necrosis factor-αRats
Publication Date：2006-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 161-163 )