Influencing factors for multi-drug resistant bacteria infection in ICU patients:a Meta-analysis
WANG Hao
DAI Kaili
ZHOU Ji
ZHOU Zheng
ZHENG Zixiang
ZHANG Jing
Abstract：Objective:To systematically evaluate the influencing factors of multidrug-resistant bacteria infection in adult intensive care unit(ICU)patients in China.Methods:Case control studies and cohort studies related to the influencing factors of multidrug-resistant bacterial infections in adult ICU patients in China were retrieved from databases such as CNKI,VIP,WanFang Database,CBM,PubMed,Web of Science,EMbase,the Cochrane Library,EBSCO,Wiley Online Library,CINAHL,etc.The search period was from August 14,2023.2 researchers conducted literature screening,data extraction,and quality evaluation.RevMan 5.3 was used for Meta analysis.Results:A total of 29 articles were included.Meta-analysis results showed that underlying diseases(OR=2.13,95％CI 1.55-2.92,P＜0.000 1),disturbance of consciousness(OR=4.27,95％CI 2.70-6.77,P＜0.000 1),hypoproteinemia(OR=3.00,95％CI 1.90-4.75,P＜0.000 1),use of antimicrobials(OR=2.55,95％CI 1.68-3.88,P＜0.000 1),duration of use of antimicrobials(OR=2.48,95％CI 1.27-4.85,P=0.008),use of ventilators(OR=1.25,95％CI 1.04-1.50,P=0.02),mechanical ventilation(OR=2.88,95％CI 1.62-5.11,P=0.000 3),duration of mechanical ventilation(OR=3.03,95％CI 1.73-5.31,P＜0.000 1),intravenous catheterization(OR=2.16,95％CI 1.45-3.22,P＜0.000 1),indurating catheter(OR=2.13,95％CI 1.32-3.423,P=0.002),length of ICU stay(OR=3.79,95％CI 2.51-5.74,P＜0.000 1),surgery(OR=1.73,95％CI 1.38-2.16,P＜0.000 1),and invasive procedures(OR=4.32,95％CI 2.08-8.97,P＜0.000 1)were risk factors for multidrug-resistant bacterial infection in adult ICU patients in China.Women(OR=0.68,95％CI 0.54-0.85,P=0.000 8)was its protective factor.Conclusion:Men,patients with underlying diseases,disturbance of consciousness,hypoproteinemia,use of antibiotics,long use of antibiotics,use of ventilators,mechanical ventilation,mechanical ventilation for a long time,intravenous catheterization,indurating catheter,ICU stay for more than 7 days,surgery,and invasive procedures are more likely to develop multidrug-resistant bacterial infections.
Keywords：intensive care unitICUmulti-drug resistant bacteriainfluencing factorsMeta-analysisevidence-based nursing
Publication Date：2024-11-30
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：8( 3996-4003 )