Risk factors for hypoglycemia in premature infants:a Meta-analysis
WEN Cheng
YAN Ling
LANG Yu
YANG Zhen
ZHANG Fang
LI Biying
Abstract：Objective:To analyze the risk factors of hypoglycemia in premature infants through meta-analysis.Methods:Literature of relevant study was retrieved from CNKI,CBM,WanFang Database,VIP,PubMed,Web of Science,EMbase,and the Cochrane Library,from the establishment of the database to December 22,2023.Each risk factor's OR value and 95％CI were calculated and combined.Results:A total of 10 documents were included,involving 4 564 patients,and a total of 11 variables were combined.Meta-analysis results showed that maternal diabetes(OR=2.24),maternal insulin-dependent diabetes(OR=3.41),maternal hypertension(OR=1.86),cesarean section(OR=1.79),gender(male)(OR=2.74),small for gestational age(SGA)newborns(OR=2.16),and asphyxia of premature infants(OR=5.27)were risk factors for hypoglycemia in premature infants.Prenatal use of magnesium sulfate(OR=0.43)and vaginal delivery(OR=0.44)were protective factors for hypoglycemia in premature infants.Conclusions:current evidence shows that medical staff should pay great attention to premature infants whose mothers have diabetes,especially insulin-dependent diabetes,high blood pressure,cesarean section for delivery,SGA newborns,asphyxia,etc.and develop personalized prevention strategies to reduce the occurrence of hypoglycemia.
Keywords：premature infantshypoglycemiaMeta-analysisrisk factorsevidence-based nursing
Publication Date：2024-07-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 2294-2299 )