Different cleansing agents for prevention of pin site infection after orthopedic external fixation:a network Meta-analysis
CHANG Zhichen
JIN Fangxu
SONG Xiangyang
Abstract：Objective:This study evaluated the probability of different detergents in preventing pin tract infection after orthopedic external fixation by using network Meta-analysis.Methods:Using evidence-based search strategy,PubMed,Web of Science,MedLine,CINAHL,the Cochrane Library,EMbase,CNKI and WanFang Databases were searched by computer for clinical randomized controlled trials of detergent in preventing pin tract infection after orthopedic external fixation published from self-construction to April 30,2023.The outcome measures were the incidence of pin tract infection and the positive rate of pin tract infection.The Cochrane risk of bias assessment tool was used to evaluate the quality of the included literatures.After the literature data were extracted,the RevMan 5.4 and Stata 17.0 software were used for data analysis.Results:Eight randomized controlled trials involving 439 patients with 4 435 pin sites were included.Of these,1 was a low risk study and 5 were medium risk studies.The results of network Meta-analysis showed that the infection rate of normal saline+1.5％H2O2+Xeroform(93.6％)and normal saline+Xeroform(70.6％)was higher than that of normal saline(62.0％).The positive rate of infection was higher in normal saline+1.5％H2O2+Xeroform(91.2％),normal saline+0.2％polyhexamethylene biguanide(85.8％)and normal saline+Xeroform(53.2％)than in normal saline(52.7％).Conclusion:Current evidence shows that normal saline+1.5％H2O2+Xeroform is the most likely to be the best intervention in preventing the incidence of pin tract infection and infection positive rate after orthopedic external fixation among many detergents.
Keywords：detergentsorthopedic external fixationpin site infectionnetwork Meta-analysisrandomized controlled trialevidence-based nursing
Publication Date：2024-04-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：11( 1149-1159 )