Risk factors for enteral nutrition intolerance in critically ill patients:a Meta-analysis
LIAN Pengmin
FAN Hongjin
GE Wei
Abstract：Objective:To investigate the risk factors of enteral nutritional intolerance in intensive care unit(ICU)patients through Meta-analysis.Methods:Literature on enteral nutritional intolerance in ICU patients was reviewed from WanFang Database,CNKI,VIP and CBM.The relevant data were extracted and analyzed with RevMan 5.3 software.Results:A total of 20 articles were included.The results of Meta-analysis showed that intra-abdominal pressure(OR=3.53,95％CI 2.42-5.16,P＜0.000 01),APACHE Ⅱ score(OR=2.17,95％CI 1.26-3.74,P=0.005),application of acid-suppressive drugs(OR=3.56,95％CI 1.32-9.58,P=0.01),fasting time＞72 h(OR=2.06,95％CI 1.47-2.88,P＜0.000 1),implementation days of enteral nutrition(OR=4.00,95％CI 3.55-4.45,P＜0.000 01),age(OR=2.05,95％CI 1.51-2.79,P＜0.000 1)and application of antibiotics(OR=5.89,95％CI 1.88-18.41,P=0.002)were risk factors for enteral nutrition intolerance.Conclusion:The available evidence shows that intra-abdominal pressure,APACHE Ⅱ score,application of acid-suppressive drugs,fasting time＞72 h,implementation days of enteral nutrition,age,application of antibiotics are risk factors for enteral nutritional intolerance.Preventive nursing of enteral nutritional intolerance should be strengthened in combination with risk factors to reduce the incidence of nutritional intolerance.
Keywords：enteral nutrition intoleranceintensive care unitrisk factorsMeta-analysisevidence-based nursing
Publication Date：2024-03-31
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1007-1012 )