Effect of chlorhexidine bathing in preventing multi-drug-resistant bacterial infections in ICU patients:a Meta-analysis
ZHANG Qin
JIA Ping
WANG Li
XIE Caixia
SONG Huiqin
FU Yanmei
QIN Ruixue
LI Xinyu
GUO Danyang
Abstract：Objective:To systematically evaluate the preventive effect of chlorhexidine bathing on multidrug-resistant bacterial infections in ICU patients.Methods:Chinese and English literature on the effectiveness of chlorhexidine bathing in preventing multidrug-resistant bacterial infections in ICU patients were retrieved from the Cochrane Library,PubMed,Web of Science,EMbase,CNKI,WanFang Database,VIP database,and CBM.Two researchers independently screened the literature,evaluated quality,extracted data according to the inclusion and exclusion criteria,and used Stata 16.0 software to perform Meta-analysis.Results:A total of 11 studies involving 23 090 patients were finally included.Meta-analysis results showed that compared with conventional warm water or soapy water bathing,chlorhexidine can reduce multi-drug-resistant bacterial infections in ICU patients(OR=0.770,P＜0.001),and the difference was statistically significant.Among them,chlorhexidine whole-body bathing can reduce vancomycin-resistant enterococci(VRE)(OR=0.664,P=0.004)and carbapenem-resistant Pseudomonas aeruginosa(CRPA)(OR=0.442,P=0.034).Still,it cannot reduce the risk of infection with methicillin-resistant Staphylococcus aureus(MRSA)(OR=0.852,P=0.193)and carbapenem-resistant acinetobacter baumannii(CRAB)(OR=0.888,P=0.537).Conclusions:Existing evidence shows that chlorhexidine bathing could reduce multi-drug-resistant bacterial infections in ICU patients,but it is only effective against some drug-resistant bacteria.
Keywords：multidrug-resistant bacteriachlorhexidine bathingmethicillin-resistant staphylococcus aureusvancomycin-resistant enterococciMeta-analysis
Publication Date：2024-01-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 14-19 )