On the Synthesis of the Green Fungicide of Trifloxystrobin
YUAN Yu
JIN Chaojun
LIU Yang
Abstract：T rifloxystrobin is one of the strobilurin fungicides ,w hich has the advantages of broad‐spec‐trum ,high activity ,low toxicity and so on .And the market of it is vastitude .Trifloxystrobin contains(E)‐β‐methoxyacrylate sbunit ,and study on the mode of action of trifloxystrobin revealed that these compounds inhibit the respiration chain of fungi .This study adopted backstepping analysis to explore two synthetic routes of key intermediates of methyl 2‐oxo‐2‐(o‐tolyl)acetate ,which began with the 1‐(o‐tolyl)ethanone and the 2‐methylbenzoic acid .Then trifloxystrobin was obtained starting from methyl 2‐oxo‐2‐(o‐tolyl)ace‐tate via reaction with methoxyamine ,bromization and condensation with(E)‐1‐(3‐(trifluoromethyl)phenyl) ethanone oxime .The total yield was 25 .7% .
Keywords：green fungicidebackstepping analysistrifloxystrobinsynthesis
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 1-7 )