Catalytic Synthesis of 5-Ethoxycarbonyl-4-(4-hydroxyphenyl)-6-methyl-3,4-dihydropyrimidin-2 (1H)-one with H3 PW6 Mo6 O40/SiO2
YANG Shui-jin
JI Wen-wen
Abstract：5‐Ethoxycarbonyl‐4‐(4‐hydroxyphenyl)‐6‐methyl‐3 ,4‐dihydropyrimidin‐2(1H)‐one was syn‐thesized from hydroxybenzaldehyde ,urea and ethylacetoactate in the presence of H 4 SiW6 Mo6 O40/SiO2 .The influential factors of the molar ratio reactant ,catalyst dosages ,reaction time and reaction temperature were discussed .Experimental results showed that H3 PW6 Mo6 O40/SiO2 was an excellent catalyst to synthesize 5‐ethoxycarbonyl‐4‐(4‐hydroxyphenyl)‐6‐methyl‐3 ,4‐dihydropyrimidin‐2(1H)‐one .The yield of product can reach 89 .7% under the optimum condition :the molar ratio of n(hydroxylbenzaldehyde)∶n(ethylacetoace‐tate)∶n(urea) is 1∶1 .2∶1 .5 ,the mass ratio of catalyst to reaction is 1 .0% ,the temperature of the reac‐tion is 90 ℃ ,and the reaction time is 75 min .The 3 ,4‐dihydropyrimidin‐2(H)‐one was characterized by melting point measurements ,IR and MS spectroscopy .
Keywords：5-Ethoxycarbonyl-4-(4-hydroxyphenyl )-6-methyl-34-dihydropyrimidin-2 (1H )-oneH3 PW6 Mo6 O40/SiO2catalysis
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 25-28 )