Progress on frontotemporal dementia
XU Yu-xuan
NAN Hai-tian
CHU Min
WU Li-yong
Abstract：Frontotemporal dementia(FTD)is the second most common type of early-onset dementia after Alzheimer's disease(AD),severely impairing patients' quality of life and increasing the burden of family care.Currently,there is a lack of reliable biomarkers for its diagnosis,and reliance on clinical manifestations is prone to misdiagnosis and missed diagnosis.Additionally,there are no approved specific treatments for FTD,and the efficacy of existing therapeutic treatments remains limited.With the deepening research on the genetic mechanisms of FTD,the diagnostic and therapeutic treatments based on this have significant application prospects.This study systematically summarizes research findings in the fields of genetic mechanism,pathological classification,diagnosis and therapeutic treatments of FTD in recent years,aiming to provide a reference for comprehensive understanding of disease's pathogenesis and clinical characteristics,and to lay a foundation for exploring novel diagnostic and therapeutic strategies.
Keywords：Frontotemporal dementiaGenesMutationBiomarkersTranscranial magnetic stimulationElectric stimulation therapyReview
Publication Date：2026-02-25
Online Publishing Date：2026-04-07(First online date of this platform, not the publication date of the document)
Pages：10( 169-178 )