Progress on the pathogenesis of Alzheimer's disease
WANG Pu-yun
WANG Cai-xia
JIA Yan-hong
SUN Yong-jie
LIU Mei-li
LIANG Fu-ru
Abstract：The pathogenesis of Alzheimer's disease(AD)has not been fully elucidated to date,posing tremendous challenges for clinical treatment.An in-depth exploration of its pathogenesis is of great significance for early screening,prevention,diagnosis and treatment of AD.This paper comprehensively reviews numerous research hotspots in the pathogenesis of AD in recent years,including amyloid β-protein(Aβ)hypothesis,tau protein and neurofibrillary tangles(NFTs)hypothesis,neuroinflammatory hypothesis,oxidative stress injury hypothesis,vascular dysfunction hypothesis,synaptic dysfunction and neurotransmitter changes hypothesis,gut-brain axis hypothesis,and gene mutation hypothesis,so as to provide references for the early diagnosis and effective treatment.
Keywords：Alzheimer diseaseAmyloid beta-peptidesTau proteinsInflammationSynapsesGastrointestinal microbiomeGenesMutationReview
Publication Date：2026-02-25
Online Publishing Date：2026-04-07(First online date of this platform, not the publication date of the document)
Pages：8( 161-168 )