Comparison between the MIND-China study and similar international large-scale cohort studies
WANG Xiao-yu
DU Yi-feng
Abstract：Alzheimer's disease(AD)continuum is characterized by an insidious onset and a continuous disease spectrum,making early identification particularly challenging.Its initiation and progression result from complex interactions among amyloid β-protein(Aβ)and microtuble-associated protein tau pathologies,vascular factors,genetic susceptibility,and other multifactorial mechanisms.Achieving precise staging across the AD continuum and implementing timely interventions are pivotal to delaying disease progression.Centered on the Multimodal Interventions to Delay Dementia and Disability in Rural China(MIND-China)study,contextualized within evidence from similar international large-scale cohort studies,this article systematically reviews the epidemiological characteristics,risk factors,imaging characteristics,multimodal biological markers,emerging intervention strategies,and looking ahead to future development directions across the AD continuum.The aim is provide an evidence-based medical evidence for formulating an early identification,risk stratification and comprehensive prevention and control system for Alzheimer's disease that suits China's national conditions.
Keywords：Alzheimer diseaseCohort studiesChinaEpidemiological monitoringRisk factorsBiomarkersEarly diagnosisReview
Publication Date：2026-02-25
Online Publishing Date：2026-04-07(First online date of this platform, not the publication date of the document)
Pages：9( 152-160 )