Expert consensus on the selection of accessory examinations for cognitive dysfunction disorders based on the biomarker diagnostic framework
Neurodegenerative Disease Special Committee,China Association for Promotion of Health Science and Technology
Shandong Provincial Key Laboratory of Neuroimmune Interaction and Regulation
BA Mao-wen
WANG Xi-jin
Abstract：Cognitive dysfunction disorders have emerged as a major public health challenge in aging societies,early precise diagnosis and management are even more challenging.Using the ATN biomarker diagnostic framework for Alzheimer's disease(AD)as a paradigm,promoting biomarker-based precision diagnosis has become an important concept in the field of cognitive dysfunction disorders diagnosis and treatment.However,the diagnostic efficacy of the ATN framework has certain limitations.Therefore,the new diagnostic pathway advocates the starting from the clinical cognitive dysfunction characteristics of patients to form preliminary diagnostic hypotheses,which then serve as the entry point for selecting biomarkers.To improve the assessment system,develop reasonable accessory examination pathways,and prioritize biomarkers with the highest informational value,the"Expert consensus on the selection of accessory examinations for cognitive dysfunction disorders based on the biomarker diagnostic framework"has been compiled.This consensus integrates a systematic summary of current domestic and international evidence,aiming to assist clinicians in the rational and effective use of diagnostic biomarkers.By promoting standardized diagnostic and management practices,this consensus seeks to enhance the efficiency of clinical decision-making,enabling accurate diagnosis and differential diagnosis of cognitive dysfunction disorders with minimal yet informative testing.
Keywords：Cognition disordersAlzheimer diseaseBiomarkersAmyloid beta-peptidesCerebrospinal fluidPlasmaBody fluids
Publication Date：2026-02-25
Online Publishing Date：2026-04-07(First online date of this platform, not the publication date of the document)
Pages：15( 129-143 )