Mechanisms and clinical advances in transcranial alternating current stimulation for the treatment of depression
YANG Xin
WANG Shu-zhe
LI Shen
Abstract：Transcranial alternating current stimulation(tACS)is a non-invasive neuromodulation technique that applies low-intensity sinusoidal currents at specific frequencies to interact with endogenous neural oscillations.By modulating neuronal firing synchrony,tACS can improve neural functions.In recent years,this technique has shown potential in the treatment of depression.This article reviews advances in the application of various tACS modalities in depression,discusses optimization strategies and future directions,and provides insights for clinical practice and further research.
Keywords：Depressive disorderElectric stimulation therapyReview
Publication Date：2026-01-25
Online Publishing Date：2026-04-07(First online date of this platform, not the publication date of the document)
Pages：7( 92-98 )